Breast Cancer Research News
Kwan ML, et al. Dietary Patterns and Breast Cancer Recurrence and Survival Among Women With Early-Stage Breast Cancer. J Clin Oncol. 2008 Dec 29. [Epub ahead of print]
In a study of 1,901 Life After Cancer Epidemiology Study participants diagnosed with early-stage breast cancer between 1997 and 2000 (recruited primarily from the Kaiser Permanente Northern California Cancer Registry) Kwan ML et al investigated dietary patterns and overall survival and breast cancer outcome. Diet was assessed at cohort entry using a food frequency questionnaire. Two dietary patterns were identified: prudent (high intakes of fruits, vegetables, whole grains, and poultry) and Western (high intakes of red and processed meats and refined grains). Two hundred sixty-eight breast cancer recurrences and 226 all-cause deaths (128 attributable to breast cancer) were recorded. Using Cox proportional hazards models, the authors observed that increasing adherence to a prudent dietary pattern was associated with a statistically significant decreasing risk of overall death (P trend = .02; HR for highest quartile = 0.57; 95% CI, 0.36 to 0.90) and death from non-breast cancer causes (P trend = .003; HR for highest quartile = 0.35; 95% CI, 0.17 to 0.73). In contrast, increasing consumption of a Western dietary pattern was related to an increasing risk of overall death (P trend = .05) and death from non-breast cancer causes (P = .02). Neither dietary pattern was associated with risk of breast cancer recurrence or death from breast cancer. This study shows that although diet does not influence breast cancer outcome, however women diagnosed with early-stage breast cancer might improve overall prognosis and survival by adopting healthier dietary patterns.